I feel personally a set of monitors and sub (s), for the same money being spent on a pair of uprights, should surpass the performance of a pair of floor standers, shouldn't they?
Any time you have woofers covering a less strenuous or broad frequency range then there is an opportunity for better clarity and lower distortion.....as long as the integration is properly designed (best stick with same manufacturer).
A sealed sub and sealed monitors instead of ported floorstanders is a great way to go.