2.2 is absolutely the way to go.
Without getting stupid or too stupid here is where you should start.
Get a pair of Harbath P3's and put then on stands the get two Martin Logan 210 balanced force subwoofers and a MiniDSP SHD to run everything. This will out perform the vast majority of systems out there. Do not be fooled by their size. The limiting factor is always the tweeter power handling ability. The Tweeter in the P3 can and is used in much larger speakers. Small speakers are special because the enclosure is so small it disappears sonically leaving a pristine image. This system will have no trouble doing 110 dB in a medium sized room. Rock to your hearts content.