regardless the device, tubes often influence the downstream signal.
12AT7s are sometimes on the input side of the amplifier and as such will flavor the overall sound one way or some other.
RCAs from the 60s for example which I own, soften up the audio a tad, adding a bit more relaxed sense of being.
from the same Era, Amperex Bugle boys step up the notes leading edges. and add more bottom end and insightfulness to the music.
I've mixed the rCACs AT7 and Bugle Boys AX7s on the output side, achieving solid dynamics while still presenting a sense of ease to the music.
with RCAs on either end, things became a bit too soft for my tastes. with Bugle boys on either side things greatly perked up.
its like baking a cake some what... its always a result of the types of tubes being used in conjunction with each other.
its a tad harrowing from time to time trying for a particular 'flavor' and the safest bet IMO is to begin by using the same brand, model and ear of NOS and if not happy wash, rinse, repeat. or try other combinations.
there used to be a website which gave pretty close or accurate accounts on various tube type and era sonic attributes called joe's tube lore.
good luck