I've ignored low ballers (not just their 1st offer - all further attempts as well) MANY TIMES because - well, this is my hobby and I prefer to conduct it in ways that are enjoyable to me. Haggling, entertaining ridiculous lines of questioning (opening with "wHy ArE U sELLiNg"), and other "techniques" annoy the heck out of me, and I'll simply quietly move on (no need for exchanging insults). It won't kill me if a component doesn't move or takes longer to find the right buyer. I generally open pricing at least a little below the recent market, so any offer well below that generally gets a cringe reaction from me. ESPECIALLY if fielded within 24 hours of posting. Sometimes I ignore reasonable offers (not official offers which have expiration - offers in message form) that are a little below my ask - in those cases I'm probably waffling on selling the piece at all around that price, and it's not a matter of annoyance; I simply didn't get around to responding (I should do better in those cases).
Now once a potential buyer proves to be a serious and reasonable fellow, I very often go over-the-top trying to be helpful in their system setup and with any questions they have. I'm very happy to share my experiences in this hobby!
And of course - once money changes hands, it's job #1 to be professional and promptly get the item delivered as advertised. No drama, no emotions!