While they are not the mains, I run Genelec 8341A's in my office where I do perhaps even more listening than on the main system, and I've been impressed with how well they hold up to, even at times exceed the McIntosh, Burrmester and SF Il Cremonese system in our den.
The 8341s, fronted by a Lumin U1 mini, Mutec MC3+, and my work Mac Pro desktop bring 95% of the musicality and detail retrieval of our main system, lacking only in max SPL and bass extension below 35Hz when compared to the much larger, more expensive and complex 7' stack of McIntosh and Burrmester boxes in our den.