The issues you'll run into are primarily reduced longevity of certain electrical components. Unless it's been upgraded, your Bedini 25/25 has electrolytic capacitors in the circuit, which contain a liquid electrolyte inside that eventually dries out. Lifespan is dependent on usage, operating temperatures and quality of the cap.
This person had to replace them in 2013 on his Bedini to fix a humming issue. https://forum.audiogon.com/discussions/repair-of-bedini-amp
So, if you don't mind the increased costs associated with the convenience of keeping your equipment running all the time, it is really up to you. I keep my stuff on if I am going to be around for a while, turn it off when I know I'll be gone or unable to listen for a while.
This person had to replace them in 2013 on his Bedini to fix a humming issue. https://forum.audiogon.com/discussions/repair-of-bedini-amp
So, if you don't mind the increased costs associated with the convenience of keeping your equipment running all the time, it is really up to you. I keep my stuff on if I am going to be around for a while, turn it off when I know I'll be gone or unable to listen for a while.