The problem with this discussion is that it’s often comparing apples and oranges. For a level playing field you’d need a comparison with one cartridge in the same arm with and without the option of detachable headshell. Like the SME 3009, which was originally available with both options. I never owned these, but I’ve made a comparison that could be regarded as sort of ‘next best’. I own an Audiocraft AC-4400, which has the option of interchangeable armpipes. There are various straight armpipes with fixed headshell as well as an S-type armpipe with SME bayonet to accommodate detachable headshells.
So just for the hell of it I made a comparison with one specific cartridge mounted in the straight armpipe as well as in a headshell connected to the S-type armpipe. Of course everything else remained unchanged, from the tonearm cable all the way to the loudspeakers.
I used a Sato Musen Zen Diamond cartridge as Guinea pig. The choice is purely coincidental, but it’s a suitably revealing albeit old MC cartridge (based on the Victor MC-L1000 direct couple but with diamond cantilever). I used the Audiocraft AS-4PL headshell to keep the comparison as ‘level’ as possible.
It may well be my aging ears, but as much as I tried I was unable to detect a discernible audible difference between both options. Direct switching was impossible because I obviously needed some time to chance over the cartridge between both armpipe/ headshell arrangements. To some folks this will likely invalidate the experiment, but nonetheless I would not make too much of a thing about this issue. If it’s flexibility you want, choose a high quality tonearm with detachable headshell option and don’t loose any sleep over it.
Contrary to Raul’s opinion I think very highly of the FR-64/66fx tonearm, but would strongly advise against having it converted to continuous wiring. If anything the very considerable market value of the 66fx will drop like a brick. Changing the internal wiring to silver could make sense though. Depending on the quality of the original wiring there can be an audible sonic benefit and it won’t have a negative impact on the market value.