I hadn't joined AG when this thread was started, or I would have contributed then.
To address the OP's issue, I have not used substances for critical listening, although I enjoy their ASCs for pleasure listening. One issue for critical listening, e.g., when comparing components, is that an ASC might interfere with the short-term memory needed to recall what one has heard. Auditory short-term memory is thought to be fragile under normal circumstances, and I think it is worsened by substance-induced ASCs.