I also owned the 5350 and the destiny is better but it's only weakness is it doesn't play extremely lound with inefficient speakers like dynaudio or revel. I've had mine shut down a time or two when really cranking some music for a while and that was in a bedroom. If you are thinking of filling a large room at a high level this might not do it. Other than that it sounds great.I've played my destiny with revel M20 dynaudio contour 2.5 and Von schweikert vr 1 and they all sound good.
I also have a simaudio i5.3 that has 80 watts compared to the destiny at 100. The sim sounds great too but is a little more finicky with the speakers it works with. It's ok with the revel great with the dynaudio and not so great with the Von schweikert. It seems to have more power than the destiny and plays with a little more authority but the destiny is great too and very musical and easy to listen to. The sim audio is a brighter more revealing sound with more refinement and space the destiny is a little warm and fuzzy compared. You would prob have a favorite side by side but either on their own should satisfy most anyone as long as you aren't used to 20k separates.
I also have a simaudio i5.3 that has 80 watts compared to the destiny at 100. The sim sounds great too but is a little more finicky with the speakers it works with. It's ok with the revel great with the dynaudio and not so great with the Von schweikert. It seems to have more power than the destiny and plays with a little more authority but the destiny is great too and very musical and easy to listen to. The sim audio is a brighter more revealing sound with more refinement and space the destiny is a little warm and fuzzy compared. You would prob have a favorite side by side but either on their own should satisfy most anyone as long as you aren't used to 20k separates.