Center speaker placement

Unfortunately I have a media niche at the front of the room that is off center. The room is 16 feet wide, but instead of my center speaker at the middle 8 feet from the sides, I will have to place it at a spot 5.5 feet from one side.
Question: Do I place the center channel over the TV? or do I place it in the center of the room. The difference is definitely noticeable visually, but from a sound perspective, will it make that much of a difference?
Thanks in advance!