Can changing speaker cables often require adjusting speaker placement?

Just switched from Grover Huffman "EX" speaker cable to Harmonic Technology's PRO 11+ which is about 6 years old.  The Huffman cable has remarkable clarity, but can also be edgy on the top end at high volume.  The older Harmonic Tech Pro 11+ is better balanced with much greater midrange detail, and lower mids detail. Bass is outstanding and tightly controlled

MAJOR ISSUE::... with the HT speaker cable, the sound is more forward and somewhat in your face. The GH cable was less so in your face and a tad more depth 

****Therefore, do different speaker cables require adjusting speaker placement, that is, in relation to the back and side walls??? .

The speakers are Golden Ear Technology's model 7  Speakers setup was made according to instructions in manual.  However, I had to work within the parameters of the room dimensions of the long axis.  For example, speakers are 22 inches from back wall, and approx. 40 inches from sidewalls. They are slightly toed so tweeters response converges at the tip of the a triangle behind my head. BTW, I sit about 10 ft from mid point between speakers  Thank you