Hi Op...many of us go through this transition.
I decided to get a streamer/DAC - I went with Moon's 280D (which is about $3k) that is a definitive step up from the Node 2i.
I do like Bluesound's interface and if Moon didn't have a good interface as well - perhaps the Node 2i would have stayed in the chain for ease of use.
I'm curious what the rest of your system includes because recently I upgraded to the Moon 390 - upgrading both my DAC and my preamp. And I've seen used Moon 390 on Audiogon recently for about $3.5