Piqued by Andre's comment, I can attest to the joy of good horns in a loft. I had Edgarhorns and Bruce's refridgerator-sized, Seismic sub when in a 2000 sq ft loft w/ 14 ft ceilings in Chicago. It was really wonderful. The space allowed the speakers to really shine ... and the speakers could really fill the loft with music.
The speakers were only about two feet from the rear wall and listening seat was about 12-14 feet away from the speakers - it was a virtually ideal set-up and provided some of my favorite listening experiences.
I was running either 2A3 or Type 45 SET amps with them.
If you have not yet committed, one of the keys to investigate is the degree to which the loft is sound proofed from unit to unit. The older lofts (unless exceptionally well-done) can be virtual tin cans w/ strings! :>)