I found that it depends on the amp. I had a Audio Research VT100 Mk II that I used single-ended for a few years. Then I switched to a front-end with balanced outs, so I switched to balanced interconnects and the sound improved significantly. The most obvious improvement is better bass extension with balanced compared to single-ended.
I would suggest finding out if your amp is a balanced design. If so, try using balanced. But ultimately, trust your ears.
Gary
I would suggest finding out if your amp is a balanced design. If so, try using balanced. But ultimately, trust your ears.
Gary