Although @mgrif104 makes good points about separating the server and endpoint (or streamer, or renderer), I would add that IME the method of conveying the digital signal may also play a role in how things sound. This is likely due to the interfacing circuitry within the two units being connected.
I am using a pretty good streamer to a Roon endpoint and then either coax or AES/EBU out of the endpoint to the DAC. However, in the cases of the Mojo Audio Mystique evo Pro and Mola Mola Tambaqui DACs, a USB connection directly between the streamer and the DAC (i.e., no outboard endpoint) seem to sound the best compared to using the DAC's S/PDIF or AES/EBU inputs.