Line level comes from the amp output (or from the speaker) but is a very high impedance (on the sub) which means it is sensing the voltage and not using any real current to drive it. The best scenario (in my opinion) would be a sub out from the pre with a built in (or external that would go between the pre and the amp if not built in) crossover. That way there would be more available current for the speakers since that power won't be wasted on something the speaker can't reproduce audibly. Without a built in or external crossover that current is still going to the speakers. So if a crossover is not possible I would prefer line level.
Hope that helps
Hope that helps