Why not, as long as you avoid making adjustments that are too high or too low, which could cause clipping, and the quality of the sound such as dynamics and microdetails remains unaffected. Especially during low-volume listening, it is desirable to apply EQ adjustments to compensate for highs and lows to achieve an equal loudness contour.
However, the questions that concern me are:
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Will the quality of sound genuinely remain unaffected with EQ?
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Should I opt for digital EQ (especially PEQ) or analog EQ?