Oy! My sympathies for the loss, but I'm sure it's not a total loss. I've spent too many years with tube components so now I always shut down everything before making swaps. I have made a similar mistake once before. A 2A3 amp I owned had a socket that allowed the tube to be put in off of it's proper orientation (some of the earlier, cheaper sockets do). It becomes a visual task to allign them and with four pins would seem a relatively simple one. Guess my eyesight isn't what it used to be. I put in the tube the wrong way and upon turning on the amp promptly fried a resistor. No big deal as the maker is a friend who lives nearby so I was able to bring it to him the next evening to swap out. He had since started using the sockets that only will allow insertion in the proper orientation.
Marco
Marco