Some wall speakers have the ability to 'aim' the tweeters.
Any woofer does better with more cubic feet in the enclosure. Some wall speakers can use the cavity within the studs, floor to ceiling, however, you need to construct that section specially for speaker use, i.e. vibrations.
Deeper Studs to increase cavity, 24" spacing at those locations, 16" spacing rest of wall, wood not sheetrock, ....
do some research about this if you care, perhaps others here know about this.