Speakers for a small room

@dcevans my space is a dedicated listening room. Only things in there are my components, acoustic panels and my chair. Its my little get away. 

If it were me, I'd get either Quad S2 or Ascend Acoustic Sierra 2 bookshelf speakers (both get raves) & stand mount them. I'd also get a pair of SVS SB-1000 or SB-2000 subs. And I'd finish that with a Marchand electronic crossover to divide signal from preamp into 2 filtered streams, hi-pass & low-pass (high for speakers; low for subs). All of this would cost ~$3-$4K maximum, leaving plenty left over for a good preamp & ~100 wpc amp.

ADS 300 with a 8" Subwoofer.

I'm surprised by some of the choices here. Your room is big enough, and has the ability to have a tower speaker instead of bookshelf size ones. The Martin Logan Motion 60XT is a great performer that will give you that ribbon style tweeter, that is so much easier on the ears. It will give you so much more full sound than a bookshelf. An all around award winning speaker. There's Monitor Audio 300 series, and the more expensive Montor Audio Platunum II Series for $5,700. Both the Martin Logan and the Monitor Audio Towers are great with all types of music, but most of all they are full range and non fatiguing. Throw just about any amount of amplifier power into them, and they will sing. I don't know what makes some prefer what they do. Choice is what makes the world go round. I'm just stating the fact that a full tower speaker like I'm pointing out would allow for a full spectrum sound that excites. Sit a bookshelf next to a really good tower speaker and I find the realism will make the tower win, time and time again. Just my 2 cents.

Also, if you are going to use subs for music.....REL subs are the only way to fly. REL connected to the amplifiers speaker outputs will match the signature of your amp, and also REL is many times faster and adds to your speaker's midrange in a way that the others mentions here don't. Go REL or go home theater, because that is the way most all of the other subs sound with music.