I've owned two pair of Vandersteen speakers and bi-wiring does provide a substantial increase in performance. Of course it depends on many factors including wire quality and amp design.
As for:
Please don't lump all speaker cables into the same category based on looks. Several cable manufacturers construct true bi-wire speaker cables and cover the exterior with decorative wrap to keep it tidy. That does not necessarily detract from performance and is cost saving compared to two separate runs of single cable.
In any case, here is the definitive answer, that is assuming you trust the guy that designed and built your speakers.
Richard Vandersteen's answer
As for:
using a true biwire (not where the cables are sheathed together except for 6 inches where they connect to the speaker, but where there are two separate lines of cable being used)?
Please don't lump all speaker cables into the same category based on looks. Several cable manufacturers construct true bi-wire speaker cables and cover the exterior with decorative wrap to keep it tidy. That does not necessarily detract from performance and is cost saving compared to two separate runs of single cable.
In any case, here is the definitive answer, that is assuming you trust the guy that designed and built your speakers.
Richard Vandersteen's answer