Obviously there are a great many variables that can be involved in this kind of comparison, but in addition to room size which has been mentioned, I would single out listening distance as well. Large multi-way speakers require greater listening distance for their drivers to blend properly, which may not be possible in a small to medium sized room. And even if it is physically possible to sit far enough away, doing so in a small room may result in side-wall reflection problems.
Regards,
-- Al
Regards,
-- Al