I know for sure that my 42.5/110 could run off the 110 power supply or be upgraded by using a Snaps or Hicap. Since the 250 has been around as long or longer than the 110 I would suspect that it would. I bought my system in the early 80's and sold it a couple of years ago here. IMHO, and based on the auditioning I did at the time, you would be better off buying a Hicap and a lesser priced Naim amp for the same total expenditure. That is exactly what I chose to do way back then.