Why do you want to replace the Panache?
It doesn't have the power you're looking for but the Unison Unico is an outstanding hybrid. I never compared it head to head with my Panache (no longer own it), but I liked both very much. I went with separates to replace the Panache, but it was difficult to get that clean midrange back. I found it in using a Placette passive pre, with an Odyssey Stratos dual-mono (180wpc). This gave me the midrange magic of the Panache along with some low end muscle. I found that Panache midrange to be addictive.
Marco